Principal investigator
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A principal investigator (PI) is the researcher, usually a doctor or other medical professional, who leads the clinical research team and, along with the other members of the research team, regularly monitors study participants’ health to determine the study’s safety and effectiveness. A PI is primarily responsible for the preparation, conduct, and administration of a research grant, cooperative agreement, or other sponsored project in compliance with applicable laws and regulations and institutional policy governing the conduct of clinical research.

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NIH Clinical Research Trials and You: Glossary of Common Terms

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